The granddaughter of John Barrymore and grandniece of Ethel Barrymore and Lionel Barrymore, Barrymore was born in Culver City, California on February 22, 1975. From there, she didn't waste much time getting in front of the cameras, making her first commercial at nine months and her first television movie, Suddenly Love, at the age of two. Two years later, she made her film debut, appearing as William Hurt's daughter in Altered States (1980). At the advanced age of seven, Barrymore became a true celebrity, thanks to her role as the cherubic Gertie in Steven Spielberg's E.T. The Extra-Terrestrial. The huge success of that 1982 film endeared Barrymore to millions of audience members, but following leads in two more films, Irreconcilable Differences and Firestarter (both 1984), the young actress began to succumb to a destructive lifestyle defined by drugs, alcohol, and too much partying. A child expected to behave like an adult, Barrymore began drinking at the age of nine and started taking drugs a short while later.

Unsurprisingly, observers began writing Barrymore off as just another failed child star when she was barely into her teens. She made a string of (largely forgettable) movies, many of which only reinforced her image as a has-been. However, in the middle of her teen years, Barrymore entered rehab, cleaned herself up, and wrote an autobiography, Little Girl Lost, which detailed her travails with drugs and alcohol. In the early 1990s, she entered another phase in her career, gaining notoriety for playing a series of vampy, trampy trailer-park Lolitas. In this capacity, she turned in memorable performances in Poison Ivy (1992), the 1993 made-for-TV The Amy Fisher Story, and Batman Forever (1995), all of which featured her pouting seductively and showing more thigh than all the Rockettes combined. Barrymore's on-screen antics were ably complemented by the off-screen reputation she was forming at the time: first she could be seen posing nude with then-boyfriend Jamie Walters on the cover of Interview magazine, then modeling for a series of trashy Calvin Klein ads, flashing David Letterman during an appearance on The Late Show as a "birthday present" to the host, and finally posing nude for Playboy in 1995.

In 1996, Barrymore's image underwent an abrupt and effective transformation from slut to sweetheart. With a brief but memorable role in Wes Craven's Scream and a lead in Woody Allen's Everyone Says I Love You that featured her as a Kelly Girl for the '90s, Barrymore's career received an adrenaline shot to the heart. She began working steadily again, and she reshaped her offscreen persona into that of a delightful and sweet-natured girl trying to mend her ways. This new image was supported by her screen work, much of which featured her as a chaste heroine. Her starring role as the "real" Cinderella in Ever After (1998) was a good example, and it had the added advantage of turning out to be a fairly solid hit. Barrymore's other major 1998 film, The Wedding Singer, was another hit, further enhancing her reputation as America's new sweetheart. The following year, the actress all but put the final nail in the coffin of her wild-child reputation of years past, starring as the nerdy, lovelorn twenty-something reporter who bears the titular condition of Never Been Kissed.

In 2000 Barrymore underwent even another character chance, from sweetheart to skull-cracker in the much-hyped, Matrix influenced big-screen adaptation of Charlie's Angels. -- Rebecca Flint, All Movie Guide.